Dear All, Today i found a solution finally to rebind the Javascript issue with support partially run with DNN Here is the key <script type="text/javascript"> function BindControlEvents() { //jQuery is wrapped in BindEvents function so it can be re-bound after each callback. //Your code would replace the following line: $('#<%= TextProtocolDrugInstructions.ClientID %>').limit('100', '#charsLeft_Instructions'); } //Initial bind $(document).ready(function () { BindControlEvents(); }); //Re-bind for callbacks (This is a key) var prm = Sys.WebForms.PageRequestManager.getInstance(); prm.add_endRequest(function() { BindControlEvents(); }); </script> ...